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Antibodies play a key role in the immune response. Since antibodies bind antigens with high specificity and tight affinity, Monoclonal antibodies are therapeutic drugs and used for vaccine development. Antibody
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The discoveries and insights made using pharmacometabolomics and high-resolution mass spectrometry, and the tradition of TDM to precisely quantify the target drug and/or metabolites can form a fundament for developing
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Analysis of biopharmaceuticals is very complex. It requires a suite of analytical methods and state-of-the-art instruments with maximal resolving power. 2D-LC provides high chromatographic selectivity and resolving power by combining
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Immunoassays have been the technology of choice for the analysis of biomolecules for many decades across a wide range of applications in research, diagnostics and infectious disease monitoring. There are
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Bone morphogenetic protein-2 (BMP-2) is an osteoinductive and osteointegrating signaling molecule. It is secreted in the human body as a glycoprotein and the molecular weight of its dimer isoforms are
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Steroid profiling can be used to discriminate between healthy individuals and individuals with an adrenal disorder, such as Cushing’s syndrome, Addison’s disease or congenital adrenal hyperplasia. Congenital adrenal hyperplasia (CAH)
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D-serine, (2R)-2-amino-3-hydroxy-propanoic acid, as shown in Figure 1a, is a well-known endogenous co-agonist of the N-methyl-D-aspartate-type glutamate receptor (NMDA receptor) that belongs to a family of neurotransmitter receptors in nerve
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Penicillin antibiotics are widely used for antibacterial treatment. The quantitative determination of these drugs in bio-fluids is constantly under a great need. HPLC is the more common analytical technique for
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Antioxidants represent a class of naturally occurring molecules that are responsible for several health properties. Antioxidants are present in various natural products and food matrices, typically known as “functional foods”.
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Bioanalysis of protein-based therapeutics has historically used ligand binding immunoaffinity (LBA) approaches. However, recently LBA has been combined with Liquid Chromatography-Mass Spectrometry, resulting in the term hybrid (LBA)-LC-MS/MS techniques. Hybrid
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