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Dr. van Dongen, initially trained as laboratory technician, became fascinated in the early 90s by LC-MS technology and immediately recognized its potential. As a result, he pursued his studies by
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As biologic drugs become an increasing segment in the overall pharmaceutical market, it is important to develop accurate and reliable methods to analyze these drugs in biological matrices. With advancements
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The idea of designing multispecific antibodies capable of simultaneously engaging two or more epitopes on the same or different antigens was developed more than 50 years ago. However, the molecular
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In recent years, there has been increasing demand to understand in vivo biotransformation of biotherapeutics and its impact on pharmacokinetics, efficacy, immunogenicity and safety. Liquid chromatography/mass spectrometry has been the
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LC-MS has become a major platform for the bioanalysis of protein biotherapeutics. The ease of method development and the high selectivity has been the key driving factor for the popularity
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Recently, the USFDA issued the new 2018 guidance document for the industry on bioanalytical validation. Due to this occasion, it would be worthy to look back in time as well
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Immunocapture-LC/MS has recently been used for quantitating therapeutic proteins/peptides and biomarkers in various matrices. The advantages of LC/MS quantitation include high specificity and selectivity, wide dynamic range, and less susceptibility
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Clinical studies on tuberculosis have shown a correlation between low drug exposure and treatment failure and acquired drug resistance. Objective was to develop a LC-MS/MS method for the quantification of
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Microbial products continue to represent one of the most interesting sources for the discovery and development of novel drugs. As a result of the massive screening of microbes since 1950,
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The discoveries and insights made using pharmacometabolomics and high-resolution mass spectrometry, and the tradition of TDM to precisely quantify the target drug and/or metabolites can form a fundament for developing
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