Penicillin antibiotics are widely used for antibacterial treatment. The quantitative determination of these drugs in bio-fluids is constantly under a great need. HPLC is the more common analytical technique for this purpose. During the last decades, Sample preparation, as a crucial step of the analytical procedure, is strongly affected and determined by this new scientific perspective. Therefore, a variety of new microextraction techniques have been developed, which can be combined with the chromatographic determination of biofluids. biological samples prior to their HPLC separation.
Read about recent trends in sample preparation for HPLC determination of penicillin antibiotics in biofluids.